The project, led by Prof. He Jianjun in COSE, is supported as the key project by NSFC in 2015.The proposed research will investigate and develop multifunctional, high sensitivity photonic lab-on-a-chip, including (1) nanowire waveguide double-ring sensors for refractive index based bimolecular detection, (2) surface-enhanced fluorescence spectroscopy and Raman spectroscopy based on spectrometer-on-a-chip and (3) absorption spectroscopy based on novel tunable semiconductor laser. By collecting weak spectral signal through spiral nanowire waveguide with surface plasmon enhancement using metal nanoparticles, a novel, efficient and highly sensitive means is provided for on-chip biomedical sensing. The functionality and integration density of the photonic lab-on-a-chip is at the international advanced level, and will promote the interdisciplinary development of biomedical sensor technology and multifunctional photonic integration technology in China.