The project, led by Prof. Zhang Hong from BME, won the first prize of Sci & Tech Progress Award of MOE. It pioneered the radioactive synthesis technology based on microfluidics, and independently developed two generations of PET molecular imaging probe microfluidic modular integrated synthesis system, which achieved a 95% increase in utilization rate of consumables and a 90% reduction in energy consumption. A novel theory named “transpathology” was proposed。It established a novel pattern of disease evaluation that combined multimodal molecular imaging and pathology and formed a complete core patent group in this field in China. The significant breakthrough from this project has effectively promoted the domesticalization of high-end medical equipment in China, improved the overall clinical practice of PET molecular imaging, and supported the precise medicine for major diseases.