This project, led by Prof. Wu Fei from CCST, won the first prize of Sci & Tech Progress Award of MOE. The project released some open resources of large-scale graph neural network learning frameworks, achieving systematic technological innovation, supporting end-to-end evolution of device-cloud models over distributed environments. This research transforms computing mechanism from cloud services and end intelligence to end-to-end cloud collaboration in the era of ubiquitous interconnection, mobile first, and AI empowerment. The research has been applied to more than 100 enterprises and institutions in many fields, empowering core scenarios such as visual and recommendation, supporting over 300 million active users with real-time online demand for 100 billion times daily end-to-end inference, and reshaping business models such as online economy and intelligent justice.