This project, led by Prof. Ren Kui from CCST, was supported by the Key R&D program in 2023. This project focuses on polymorphic networks endogenous safety and security (PINet-ESS), which encompasses the research on the PINet-ESS architecture based on structural encryption, building a trusted identification system and authentication mechanism for the polymorphic network (PINet) space, proposing active defense adaptive control technology, developing a hardware and software collaborative verification platform for PINet-ESS, and establishing a complete PINet-ESS defense and verification framework. This project is expected to solve the issues of intertwining network security and functional security in PINet’s environments from the architectural level, to address unknown threats effectively and enhance the overall security of cyberspace.